Liverpool central defender Joe Gomez has been injured on international duty with England.
The 23-year-old suffered the injury during the build-up to the game against the Republic of Ireland on Thursday.
Liverpool already have Dutch centre-back Virgil van Dijk facing a lengthy spell on the sidelines.
Van Dijk has had surgery on a knee ligament injury picked up against Everton in a 2-2 draw on 17 October.
The Premier League champions have also been without Fabinho, who had been deputising in defence for Van Dijk, because of a hamstring injury.
Additionally, Liverpool have an injury concern over right-back Trent Alexander-Arnold, who was taken off during a 1-1 draw against Manchester City on Sunday.