The games in the Round of 64 in the Women’s FA Cup will be played from Friday, February 4 to Thursday, February 10, 2022.
The Women’s FA Cup Committee released the fixtures on Friday, 28th January, 2022.
Defending champions, Hasaacas Ladies will begin their title defence at the Gyandu Park against Fiase Golden Royal on February 7, 2022.
Last season’s runners-up, Ampem Darkoa Ladies take on Soccer Angels in Techiman on Friday, February 4, 2022.
Full list of fixtures:
| Date | Home | Away | Venue | Time | |
| Sat. 5th | Ave Shinning Ladies | Dream Big Ladies | Ave Havi JHS Pk. | 3pm | |
| Sat. 5th | Anlo Ladies | Agave Glad Ladies | Some Hnr. High | 3pm | |
| Sun. 6th | Polilce Ladies | Ridge City Women | McDan La Town Pk. | 3pm | |
| Sat. 5th | Immigration Ladies | Blessed Ladies | McDan La Town Pk. | 3pm | |
| Mon. 7th | Hassacas Ladies | Fiase Golden Royal | Gyandu Park | 3pm | |
| Sun. 6th | Ankwansoman Ladies | Ahantaman Ladies | Ankwanso JHS. Pk. | 3pm | |
| Sun. 6th | Hassport Ladies | Amenfi Ladies | Effiekuma Police Pk. | 3pm | |
| Sat. 5th | Berry Ladies | Valued Girls | Madina Astro | 3pm | |
| Wed. 9th | La Ladies | Ideal ladies | McDan La Town Pk. | 3pm | |
| Sat. 5th | Army Ladies | Rock Ladies | El Wak Stadium | 3pm | |
| Mon. 7th | Faith Ladies | Ningo Ladies | Carl Reindorf | 3pm | |
| Sat. 5th | Christ Angels Ladies | Thunder Queens | Darkuman Okwahu Pk. | 3pm | |
| Sat. 5th | Rootz Sistas | Unick FC | Yilo Krobo SHS, Somanya | 3pm | |
| Fri. 4th | Mfantsiman Royal Ladies | Ladystrikers FC | Cos Pk. Saltpong | 3pm | |
| Mon. 7th | Oforikrom Ladies | Sea Lions | Okese Park, Ejisu | 3pm | |
| Sun. 6th | Soccer Intellectuals | Charlton Ladies | Aduyaw Assaan, Ajumako | 3pm | |
| Wed. 9th | Combines Forces | Essiam Socrates | Yamoransa Confidence | 3pm | |
| Sat. 5th | Jama Vision Ladies | Prisons Ladies | Drobo SHS Park 1 | 3pm | |
| Wed. 9th | Fosu Royal Ladies | Dormaa Candy Soccer | Ohene Ameyaw | 3pm | |
| Sat. 5th | Kumasi Sports Aca. | Supreme Ladies | Bantama Astro | 10.00am | |
| Fri. 4th | Ampem Darkoa Ladies | Soccer Angels | Ohene Ameyaw | 3pm | |
| Sat. 5th | Ashtown Ladies | Dreamz Ladies | Bantama Astro | 3pm | |
| Sun. 6th | Subayo Golden ladies | Nana Afia Kobi Ampem | Obuasi Snr. High Sch. | ||
| Sun. 6th | Fabulous Ladies | Dynamite Ladies | Bantama Astro | 3pm | |
| Sat. 5th | Royal Ladies | Kpongo Ladies | Islamic Snr, High, | 3pm | |
| Wed. 9th | Kunkua Ladies | Tamale Super Ladies | Kunkua SHS | 3pm | |
| Wed. 9th | Liberty Queens | Bolga All Stars | Zorkor SHS Pk. | 3pm | |
| Tues. 8th | Nasara Ladies | Bagabaga Ladies | Aliu Mahama Annex | 3pm | |
| Sat. 5th | Northern Ladies | Pearlpia Ladies | Aliu Mahama Stadium | 3pm | |
| Tues. 8th | FC Savannah | Young Queens | Aliu Mahama Stadium | 3pm | |
| Tues. 8th | Dahinshali Ladies | Real Crusaders | Aliu Mahama Annex | 3pm | |
| Tues. 8th | Kpanvo Future Ladies | Yoo Ladies | Aliu Mahama Annex | 3pm |