Raphael Varane will be out for around a month after the Manchester United defender suffered a hamstring injury against Atalanta.
The France international only recently returned from injury but will now miss United’s Premier League match at home to Manchester City on Saturday.
A month-long absence would see Varane out of United’s next two matches after the international break – against Watford and Villarreal.
He would also likely miss the trip to Chelsea on November 28, and he could be a doubt for the home match against Arsenal on December 2.
“The club confirms that Raphael sustained a hamstring injury, which is expected to keep him out of action for around a month,” United said in a statement on Wednesday.
“We’d like to wish Raphael all the best as he works on his recovery.”